I really appreciate the kind of information brought forth by the OP. Doctorbob, I understand your concern about Low T, but do you have a recommendation. To help with low T, Other than going on a prescribed treatment. Thanks.Oh yeah, [sarcasm]testosterone supplementation is the cure for everything.[/sarcasm]
It has some VERY nasty side effects and the positive aspect of supplementation is sort of underwhelming.
ADVERSE EFFECTS ASSOCIATED WITH TESTOSTERONE ADMINISTRATION
Basaria, S., et al, N Engl J Med 363(2):109, July 8, 2010
In this relatively small study of elderly men with low testosterone levels, limited mobility and a high prevalence of chronic disease, supplementation with transdermal testosterone was associated with an increased risk of adverse cardiovascular events
LOW SERUM TESTOSTERONE AND MORTALITY IN OLDER MEN
Laughlin, G.A., et al, J Clin Endocrinol Metab 93(1):68, January 2008
Progressively lower testosterone levels below the median were associated with a step-wise increase in the risk of death, but there was no survival benefit among men in the four highest testosterone deciles when compared with those having mid-range levels.
EFFECT OF TESTOSTERONE SUPPLEMENTATION ON FUNCTIONAL MOBILITY, COGNITION, AND OTHER PARAMETERS IN OLDER MEN
Emmelot-Vonk, M.H., et al, JAMA 299(1):39, January 2, 2008
Despite a favorable effect on lean body mass, testosterone supplementation for six months did not improve any patient-oriented outcomes, and may have adverse effects, in older men with a low-normal initial testosterone level.
TESTOSTERONE AND CARDIOVASCULAR RISK IN MEN: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED, PLACEBO-CONTROLLED TRIALS
Haddad, R.M., et al, Mayo Clin Proc 82(1):29, January 2007
Trial methodology was problematic in that the included studies had limited reporting of features that protect against the introduction of bias. The duration of follow-up exceeded one year in only four trials. Testosterone supplementation appeared to have minimal effects on lipid profiles, blood pressure and glycemia in men with low, or low-normal to normal testosterone levels. In six very small trials the cardiovascular event rate (cardiovascular death, fatal and nonfatal MIs and other events) was 8.7% with testosterone supplementation (14/161) and 4.8% in controls (7/147) (odds ratio 1.82, 95% CI 0.78-4.23). Three trials involving men with coronary artery disease reported supposedly beneficial EKG changes with testosterone supplementation, of uncertain clinical significance