I typically carry via a CTAC Infidel IWB position right around 8o'clock (I'm a South Paw).
When sitting in the car / driving, this presents two problems:
1) Feels like I'm sitting on a chunk of metal (most likely because I am) and
2) No chance in hell that I could draw effectively from 8o'clock while seated.
I've recently experimented with keeping the gun inside the Infidel and placing the entire rig in the right appendix pocket of my vest (closes with velcro) where I would draw it using a cross-draw technique. Its still not the best, as my seatbelt blocks access and I'd have to work around it to draw in a classic car-jacking scenario.
I'm considering going MacGyver and building some sort of rig which would rest inside the driver's side door-bin (open compartment in the bottom of the driver's side door where most people keep umbrellas & maps & such).
I'd be curious as to how you all manage the In-Car scenario so as to ensure that you still have good / clear access to your weapon while driving.