Good thing you clarified, I was wondering if you meant "from the bottom" or "from the front"
I generally fall into the "lock it up when drinking" crowd, but there are two places I drink. If I go to the bar, I can't take it with me anyway in WA, and I won't be driving after, so it gets locked up at home or stashed in the vehicle someone else will be driving home. No need to clear it, as the holster goes with (IWB holsters feel funny when they're empty). If I drink at home, I stuff it in the safe or the 'temporary hiding spot', and again, no need to clear as it's secured. But drinking is, for me, a very rare occurrence (as in, maybe four times this year so far, and that's more than normal)
Also, as
Brad426 mentioned above, be careful with rechambering the round more than a few times. I've never heard of primer problems, but
bullet setback (and therefore overpressure) is a big concern in most handguns. I mark the "top" round and start cycling it from the bottom, but some prefer to just toss that round in the 'range' pile after a coupe chamberings.