In my line of work, I need to carry very discreetly. Often, an OWB holster is out of the question, and I never liked IWB holsters, ankle holsters, and bellybands, and I don't think off-body carry is a good idea.
So, I settled for pocket carry, which necessitates a relatively small and comfortable handgun. I have large, deep, and heavily reinforced pockets, which can accomodate any gun with a length of 7'' or less. The gun should also be without sharp edges that snag, and is preferably a slim, single-stack pistol (I prefer pistols to revolvers).
I got used to pocket carry, and realized that it is incredibly comfortable. That means it is easy, and even second-nature, to carry anytime, anywhere. Actually, nothing is more comfortable or natural, in my opinion. And if I'm carrying everyday, everywhere, and I regularly maintain and practice with my weapon, then I certainly feel protected too.
You might say I'm more toward the comfort side, but I believe I have a good balance of both that fits my needs perfectly. Every man must find his balance based on his needs and preferences.