Maybe I am the redneck wierdo, but IMO the only "safe" for guns in the house that works is diligently teaching the kids to be safe around guns. I have lots of kids in my house and never worry about them because they ALL know how to handle a firearm.
That said, most everything I have is kept in the safe. My EDC stays on me until bedtime then goes by the bed. However, the HD shotgun is kept with a full mag and empty chamber, unlocked with the safety on, sitting on a rack in the bedroom. It's up high enough for small visitors to be unable to get to, but accessible to my wife or me in a hurry.
My philosophy is that if I am going to need a firearm I am going to need it NOW. Not in 90 seconds when I can get it unlocked. So I can't keep them locked down like some people do. That to me means that my kids need to know guns inside and out. I train them by shooting with them, hunting with them, letting them help me clean and inspect my firearms, and continually and vigilantly teaching them the four rules.
IMO that is the only path that works.