Just bought a Ruger 38 cal LCR snub and tested a couple loads today.
First bullet is a Remington 125+p. This bullet chronographed an average of 910fps and opened to .42cal measuring one direction and .50 cal measuring the the other direction on the face of the mushroom.
It penetrated 4 one gall size water filled milk jugs. The outside temperature was 75 degrees.
Second bullet is the Remington 158+p LSWCHP. It opened to .62 cal and penetrated 3 milk jugs. This bullet chronographed to an average of 810fps.
I was surprised that the recoil was a little more with the 125 grain and it penetrated deeper than the 158. Still I belive the 158 with the larger mushroom will work better for defense. My reload is always plain old swc just in case deeper penetration is needed.