"When I think of all the men killed quite handily with a black powder 36 cal round ball, it makes this issue almost laughable. "
Yes, it's such a moot argument about what's "best." The "best" debates are usually laughable.
A miss with anything is never as good as a hit with something, short of using nukes. Is a .44 Magnum more effective, thus better, than a .380? Not if you miss it isn't. What's best for one may not be best for another. I usually add my caveat to use whatever you're comfortable with, be it the make/model/caliber and capacity of weapon, the type ammo used, the number of extra mags carried, whatever. There's seldom a "best" answer for anything. Only I have to account for the gun/ammo/# of mags carried. No one else need to. They can utilize whatever they wish and are comfortable with--but that does not make it "best."