As my formerly stronger right wrist degenerates with age, I can see myself toting a .22 LR Beretta Cheetah on that side, eventually. The snappy .40 is already too much, the mellower .45 is getting to be too much, and I fear the day 9mm becomes too much. I do plan to keep carrying something more powerful for the other hand, such as .38/.357 revolvers. (I am not blaming the .40; most of the damage probably dates to my big-bore magnum revolver days.)
I already practice, mostly, with .22 LR, with a K-frame S&W Model 17 and a .22 conversion unit on a 1911. I am in an austerity period, but if enough of my holiday-related overtime pay makes it past federal withholding, I might layaway a Cheetah next payday.