Having been involved in ballistic testing as a cop I have seen these rounds tested. What you will end up with is a .40cal hole punched through the intended target. Temporary Stretch Cavities with these loads are basically nonexistant as the energy the round has is used to penetrate the target organism. The Permanent Crush Cavity is simply going to be the .40cal "rat-hole" you bore through it with the shot. To kind of illustrate this I have attached a link below to a video (you may have already seen similar ones). Marshall and Sanow's study has the 40S&W FMJ at roughly a 50% stopper, which roughly is equal to the 9mm and 45ACP Full Metal Jacket loads. Basically using this load, even in a trunjent cone form, equates to punching holes through them till you hit something worth shooting.
Ballistics test - 40 Cal - Car Door + .25 inch steel plate - Penetration test (trailer) - YouTube