My favorite is a 35 oz. .38 Special K-Frame revolver followed by a 39 oz. full-sized 1911 .45 ACP. I've found myself toting a Colt Detective Special .38 Special weighing 21 oz.
Ammo is always the +P 158 grain lead SWC load, generally Remington or its handloaded equivalent. For .45 ACP it may be Corbon 230 grain JHPs or plain ol' 230 grain ball.