Far more important is where you put the round. But for what it's worth, I like speer gold dot 147 gr because the deep expansion cavity doesn't get as clogged up with clothes and stuff as the lighter rounds. This gives more consistent pentration and expansion. (HP rounds that don't expand tend to overpenetrate, which of course means there is a lot of energy that went through the BG instead of doing it's work on him. Thats my $.02.