For ammo with excesive setback,remove bullet and dispose of powder, the primer can then be fired in your pistol. I would suggest that you buy a bullet puller for those times that it may be needed. If setback is real minor the round may be fired. A lot depends on the caliber. .40 smith and wesson has higher pressures so any setback would be dangerous. .45 is less damgerous to fire with setback because normal pressures give more lattitude to the max pressure. 9mm loaded at normal pressures is also les dangerous and can be fired with some setback. I would say that if there is any doubrt then disassemble the round. The poweder can be spread around plants outside.