On gun forums you always see arguments over what is the best caliber. I often find it interesting to hear from those who strongly believe in one caliber or another, what they consider to be the weaknesses of their caliber. I've noticed this most often when hunters honestly talk about their cartridge, caliber, round, etc. choices.
For me, with the .357 Sig, while I carry it for penetration, I'm constantly considering the fact that could also be a weakness. Natually the cost of the round, and difficulty related to reloads, are other negatives. Lastly, I'm to a point that I prefer the recoil of a .45 ACP, but stick to .357 Sig, because I like the additional capacity.