I promise this isn't meant to be another magic bullet post. I a not very familiar with much of anything when it comes to ballistics. From what I understand a bullet coming out of a shorter barrel generally has less velocity then a bullet coming out of a longer barrel. I also know that to some extent velocity is key for reliable expansion and penetration.
I'm guessing that the heavier the bullet the less velocity is produced. So that being said when it comes to the general weights of .45 (180,200,230) would it be advisable to use a slightly lighter bullet (200g) for shooting out of a 3.25 barrel or is the difference really neglible?