Rather than offer my specific carry considerations, let me offer some philosophy for a first time buyer. Stick with a caliber that has proven performance: 9mm/38 special would be the minimum. They pass LE and FBI performance minimums. It just makes me ill when I'm at the gun shop and see salespeople pushing mouse guns, especially all the new .380s that every manufacturer has unleashed on a convenience oriented public. They sell "peace of mind" the same way a cemetery does, but if you're interested in saving your life sometime, buy an effective caliber. You see, any gun can kill somebody.
I can kill someone with a sharp pointy stick, however, I carry a gun because I want to STOP someone from their attack NOW. Shoot someone in the belly with a small caliber, chances are they're still going to still be a threat until they bleed out. Shoot someone with a .357 or a .45, it probably won't matter where you hit them. You've just removed a fair portion of their beloved person, and probably have either incapacitated them permanently or removed their ability or their will to continue their attack.
I'll second the advice above: research. The internet is great, but understand, you could be reading reviews of gold bricks, and still find some opinionated and prolific person who hates them. You kind of have to examine opinions with a grain of salt. Get some books on carry conceal. Mossad Ayoob is probably the best, if not the most well known, but there's others. Here's a website aimed at women, but lot's of great advice and guidance for anyone:
Cornered Cat - Table of Contents
The benefit to buying a well known brand name is several fold. Reliability, customer support, and resale value to name a few. Accept that fact that no one gun will be perfect in every aspect, and you'll probably own a few before you nail down your favorite weapon/holster combo. Having said all that: buy a Glock.
