This is a discussion on If you were to pick one? within the Defensive Carry Guns forums, part of the Defensive Carry Discussions category; Glock 23...
Glock 23 - CZ 452 ZKM Special
Walther P22 - LMT STD 16
Mossberg 500 - Kahr P380
Henry H001Y - Winchester 12
Smith & Wesson M&P Shield
S&W 640 - .357 and .38 cover a wide range of possibilities.
The Colt Combat Commander.
See my avatar, at left. GP100.
Actually, for all-around use, a 4" or 5" barrel would be indicated. (I have those, too.)
To be clear, I would still need a SIG P229 for my duty holster, due to PD rules, but I consider a police duty pistol to be a different role than "all-around use," and, the original post's scenario did not specify that the all-around handgun had to be one's ONLY handgun.
Edited to add: Yes, I just re-read the original post. One all-around pistol. The language did not exclude other handguns for specialized purposes. My above reply stays the same, of course.
For one all around gun for SD, HD and hunting SP101 4" 357.
If I could only have one handgun I would go with a stainless .357 magnum revolver with a 4 or 6 inch barrel. Probably a S&W 686. With different loads it would easily cover anything I'd be likely to meet in the lower 48.
If you talking about carry guns, I'd go with a compact Glock.
Springfield XD 45 service model...13 rounds of 45 plus 1 in the throat, pretty hard to beat....
Carry Gun: Glock 19
Fullsized 1911, .22 conversion kit and a Mec-Tec Carbine Conversion Unit
Gp-100. That tank will kill something if I hit em with it! And you can NOT argue with a .357 magnum!
"Better to keep your mouth shut and be thought a fool than to open it and remove all doubt" ~ Mark Twain
Its a tie.....
When I leave the home port:
S&W 642 Airweight, Ruger SP 101, Colt Detective Spec., CZ RAMI, Kahr PM9, Kahr CW40, S&W Model 10-7, Glock 30, 19, and 26, Browning Hi Power, CZ82, Colt Commander, Dan Wesson PM7, Ruger LCP
A revolver in .357 mag caliber, 3 " to 6" inch barrel. This will give you reliable function with a wide variety of available ammunition.