I'm with the majority here. I don't want any manual safety on my defensive firearms. I simply want to point and pull the trigger.
During the last two seasons duck hunting, I've missed several shots simply because I forgot to take the safety off my shotgun. Since I hunt with several other people, safeties are always on until it's time to shoot. The problem is that in the excitement of the moment, it's easy to forget the simplest things. The good thing is that those weren't life and death situations.