I won't bet my life on a rimfire. The 380 is as light as I'll go for the brain stem shot. The brain is still too iffy. The brain stem is 100% instantly incapacitating and back of the bottom of the nose and between the ears and about the size of a lemmon. I will take a closer look at the Kahr 45, but the P3-AT was my BUG before it started living in my wife's pockets. I'm back to the NAA 380 for awhile. A 4" 1911 will always be my first thought and last resort. Like Clint Smith said, I won't confuse comfortable with comforting.