How about one of those single stack 380 berettas that have tip up barrels and can be fired condition one? They don't make them anymore, I dont believe, but that might be the way to go for her.
To load it, all she needs to do is flip the switch on the side and the bbl pops up. She can carry it cocked and locked and practice her presentations. I remember reading sometime back that Massad Ayoob was able to arm a fellow with severe arthritis with one of these and it worked out well for him.
A check at the local gunstores or gunbroker might be able to turn a used one up.