Shot Placement v. Caliber
Agreed. Moreover, I would stipulate that a shot through the eye with a .22 is going to kill just as fast as a shot through the eye with a 45.
Originally Posted by HotGuns
However, in a highly fluid situation where both parties are moving between cover, or trying for position, an extremity shot from a .22, .380 or even a 38sp is not going to have the same "shock to the nervous system" as a shot from a .45. Just in cross sectional density PLUS velocity, it is going to be a much greater effect, if the bullet that strikes a hand or bicep is a 45. I don't care if the smaller round is tumbling or expanding, because the 45 may be doing so as well. The shock is still going to be greater.