Tough question. I think the majority of 'what to buys' come from people asking what fits their criteria. Even your followup is sounding like that: "I have large hands, So a larger frame handgun is probably going to fit me best, whatever I purchase It'll need to be comfortable..."
I'm tall, skinny, and although I can manage a number of what I've got, I'm currently finding even a P11 to be annoying to carry, sending me once again into a corner of criteria. Sure, a 1911 might be the perfect carry for many people, but my criteria I'm currently looking for say otherwise!