I went away from Glocks for a while and went to a Sig 220. But I just returned to the dark side. I picked up a Glock 21 SF and immediatlely shot it better than the Sig 220, which I have been shooting for years. Plus Glocks typically have a slightly higher capacity than other semi's of similar size.
As for grip comfort, I used to say that Glock grips felt like a 2X4, but recently they seem to point very naturally. Sure the grip texturing is a little too aggressive for my taste, but I could have a reduction done if it starts to bother me too much.
I would have to say the Glock wins out over the Sig. But other's may disagree.