Something very simple about the 'guns' I carry... and I do carry a few different ones..... I pull the trigger and they go BOOM. Period. None of them are of a design that I do anything other than that. No decocking, safties to click, etc.
I can do a wheel gun easier than a mag change, but I can do either quickly. It's like shooting a rifle and a shotgun, both load differently... but I have no trouble shooting either one.
Practice, be versatile.
I can fly a lot of different airplanes, I haven't gotten confused what airplane I was in yet.