Question: How often do you really need to pull that big heavy pistol? Maybe all the weapons you are considering are not practical for your situation.
I went with smaller lighter gun for better concealment. Depending on the area and risk assessment nearly all the time I only need small and light. P3AT from Kel Tec fits the bill a very high % of the time, and while it is only a 380 it goes bang every time and shoots to point of aim. If situation calls for it I just move up in caliber, size, and weight.