When standing, 4:00 is most comfortable because it rests against a flat area of my body behind the hip. but if I lean over the gun butt prints, and if I sit in a chair or in the car the gun jams into the seat behind me and is uncomfortable.
I've found that 3:00 with a severe (25 degrees) forward cant works best all around. I can sit in chairs or couches, drive my car, bend over, etc. with no discomfort or printing: and I can draw from a seated position.