Well, I purchased an item from someone on Craigslist the other day, and planned to meet up with him on my lunch break to pick it up. I didn't have enough time to change out of my work uniform, and I can't wear a belt and holster on my work pants. I'd normally just leave my gun in the glove box (I can't carry at work, and I have to run errands now and then), but this situation called for going armed, so I cleared the chamber and Mexican carried it SOB (there was no way in hell I was going to walk around with a .45 pointed at the boys, chambered round or not!).
Although it was extremely uncomfortable while sitting (to be expected), I was fine once I took the first few steps and realized that my G21 wasn't going to go sliding down my pants. The worst part about it was trying not to laugh about the fact that I was Mexican carrying.
I don't know how the guys who make a habit of this can stand it for an extended period of time, and I couldn't imagine trying it with a hot-chambered Glock....one slip or wrong move, and POW!! instant falsetto.