I use a C-Tac; its cant is adjustable and I keep it in the normal cant configuration. Most strong-side concealed carry holsters have similar cants, with the barrel axis pointing rearward of vertical.
I am probably revealing my ignorance of a fundamental point here, but I wonder how holsters came to be this way? When I am standing and touch my hand to my waist, seems like a holster tilt with the barrel pointing forward of vertical would actually be a better angle to fit my hand's natural angle. The standard cant causes the butt of the pistol to be parallel to my forearm, until I twist it around to grasp the pistol.
I must use quite a bit of the flexibility of my hand, wrist, and arm to grip the pistol holstered in the standard cant. The only explanation that occurs to me is that the standard cant makes the pistol conform to the body more closely and minimizes the bulge, even though it is harder to grab. Concealment overrides utility?