If for some reason someone can't stand being on a shooting range with a bunch of guys for a few days, taking a class which does not even involve rolling around on mats trying to choke each other out or beating the hell out of each other, what makes someon think they can deal with agressive men in real life?
Maybe I'm looking at it from a guy's point of view, but women in class aren't really that noticable.
During the down time I'm usually too busy drinking water to make annoying small talk with anyone...and during the class, I have my eye on the front sight rather than on someone else who's going to possibly beat my score on the final.
As to holding your own in a co-ed class...draw without wasted movement, put the bullets in the place they need to go, reload faster than everyone else, and generally run your weapon without looking like a flounder out of water, and you'll do great.
As to the differences between the kinds of class - based on the names, it's marketing mostly, and a little bit of mindset.
A "combat pistol class" may focus more on the running of the weapon itself, less on the lawful use of deadly force.
A "defensive class" might take more time to deal with when to use the gun rather than how.
And "tactical" - If you call it tactical, someone will pay for it. It's marketing. Doesn't mean it is bad...just look at the lesson plan, not the class name.