This is an article by Michael Janich, a well known blade fighting & self defense expert. In the article he covers some techniques designed to incapacitate an attacker quickly to the point where he will be unable to continue an assault regardless of size, intoxication, or determination. The techniques are a mechanical approach to the human anatomy. Severing certain ligaments and tendons have proven to be a more reliable method of ending an attack, opposed to attacking a person's vital organs or major arteries.
I particularly like the method called "defanging the snake" in which you the severe the tendons on the inside of your attackers wrist and forearm rendering him absolutely unable to hold any type of weapon. Check it out!
Knife Stopping Power