Front sight post flush, rear sights centered and 8/3 minus 2. This is for 25 to 200 yards. Only adjust the front sight post up or down for this distance.
When you move to three hundred yards, click the rear sight up to the 8/3 setting and adjust for windage as needed.
Go back to 500 yards click the rear sight up to the #5 setting. This should be sufficient for humanoid size targets.