I am a lefty and all 3 of my ARs are right handed. I just put in an ambi safety and run them. The lowers are exactly the same on a left handed AR as on a right handed one so there isn't any real difference with the controls.

My bolt guns are left handed but other than that, I have run right handed guns all my life.

My dad had a Remington 1100 that would eject the brass right off my forehead. I don't shoot that gun anymore. Bang, OUCH!...bang, OUCH! Talk about a sure way to develop a flinch.