Back a couple lives/jobs ago, our cruiser gun standard (didn't have a rifle in the car, just the shotgun) was alternating 00 then slug. I asked why and got several different answers, one of which I think was was along the lines of "why don't you get yourself a warm cup of shut the hell up." We had a high-tech ultralight reload system too - they were made of a wood fiber composite material, held five rounds each, and you could quickly tell what kind of projectiles were in each by what was printed on the sides.
Today, I'm a simpler man. 2 3/4" 00 will do any job that needs to be done inside the house, so that's in the mag and on the side. I've got a boxes of 00 and 1 Oz slugs in the ammo boxes in different barricade rooms for the worst case scenario. At room ranges, I'm sure #4 would do just fine, but then what would I bring to the turkey blind? I'm with gasmitty about sabot - if I need that, a rifle is a better tool for the job.

