Over penetration would be a concern. The inital loads probably should be birdshot, which at less than 7 yards (max dimension of most normal houses) would be effective but rarely pass through two layers of drywall. Glasser safety slugs for HGs help in this regard too.
There is not substitute for training, learning the limits of manuverability is always an eye opener. I would rather have a high capacity HG than a SG for searches, a SG for defending in place - just my preferences.