Do you reload? If you don't, I'd seriously consider going to 35/357 for your caliber. Factory 45 Colt is expensive.
I haven't handled a new Uberti in a while (Uberti, Cimarron, Navy Arms) so don't know if they've changed this or not, but here's the one problem I've seen on several of them in the past (including the Cimarron I own).
(part of this is speculation on my part, some isn't)
Until the advent of Cowboy Action Shooting, most of these guns when they were sold were occasionally fired wall hangers. Because of this, Uberti had the habit of timing the guns closely so that the bolt just popped up into the lead-in notch so as to not touch any of the cylinder and create a "ring" on the cylinder. Because of this late timing (in the gunsmith trade they refer to it as a "late rising bolt"), the guns worked fine as long as you cocked them easily and not overly fast. But, if you're going to compete with the gun, especially a cylinder full of 200-250 grain 45 Colt rounds, and cock the gun quickly, it can lead to over-rotation of the cylinder and cause you to have to go around more than once to get all chambers fired.
If at all possible, buy one that's in stock from a local dealer and that will let you slowly cycle the action. If, while slowly cocking the gun, you see the bolt pop up just inside the lead-in notch, you will probably have over-rotation problems if you cock it hard and fast. If it pops up before the lead-in notch you'll be O.K. for performance but it will leave a ring around the cylinder eventually.
Lastly, remember that for safety's sake, these guns are 5 shooters. Load one, skip one, load four, cock and lower hammer. This leaves your hammer resting on an empty chamber. NEVER carry one of these guns loaded with 6.
Hope that helps some.