As with any situation there is no stock answer that applies to all one may encounter, and a lot depends on where you live.
City folks would be best off to consider something that will not penetrate through walls and perhaps cause collateral damage, while with folks out in the country that would not be a problem.
There are 2 weapons at my bedside, a 12 guage, short barrel pump, chock full of "00" buck, and a Glock 30 with Viridian Green Laser mounted. I am quite comfortable with these close at hand but could not tell you which I would grab first until a situation arose that required deadly force. For example: Before the invasion of Normandy in 1944 there were thousands of pages written on just how this battle would be fought......but after the first man hit the beach all of that brilliant planning went out the window, and by & large everything after that was played by ear, or as situations arose.
Now I have to 'plug' what most would consider nothing more than a 'cap gun'. but don't sell this little baby short. If we are going out to a nice place to eat (not Micky Ds, Burger King or Taco Bell), where there are lots of folks in close proximity, I carry my wif'e's S&W M-317, a 10-ounce, 8-shot .22 caliber wheelgun that fits with comfort and ease in a shirt pocket like a pack of smokes, and in close quarters the little 40 gr. hollow point stops when it hits and goes no further.
Of course we all know that opinions are like a--holes, everybody has one, and there will never be an opinion that satisfies all folks or all situations.