Yes-I don't disarm once arriving home. My 75% EDC is a 642 in a pocket holster, so I'll even carry the snubbie in PJ pants, gym shorts or sweats (I always make sure to buy them with front pockets deep enough for this specific purpose). I can use the pistol or revolver to get to my rifle or shotgun if needed. I don't have guns placed around the house-my kids are 13 and 15, and while they are firearm safety savy, I can't speak for their friends and don't need that issue.
My hypervigilant German Shepherd/Belgian Malinois mix also gives me plenty of warning when someone walks near my house, so I'm never caught by suprise when someone comes to the door.