Great responses! Several have mentioned points I hadn't thought of.
To clarify a few things:
1) I have already taken the NRA Personal Protection in the Home course (2 day class) and read half a dozen books on related topics (Massad Ayoob and others). I will be taking the PPOTH course when it's time to renew my CC permit again. I'm a big believer in training.
2) I'm familiar with the MS statutes and Castle Doctrine case law. (Dan Rather did an excellent HBO special on the Castle Doctrine in MS, if anyone is interested. My instructor is in it.) I have no legal concerns about shooting a strange man who is forcing entry at my home; this post was to discuss 'tactical' considerations.
3) When I said 'get my gun', I meant a REAL gun.

My pistol is on my hip around the house, right up until bedtime. In the scenario I described, I would get my
HD gun (pump shotgun that's loaded with the defensive 'disc' style ammo). I have seen the ballistics on long guns vs handguns and I am aware that handguns just don't have much stopping power (especially the smaller calibers I carry). What's that saying about a handgun being used to fight your way to a shotgun?

Anyway...
I was leaning towards staying in a more open area just so I'd have more options. It would be a very.bad.deal. if I were trapped in my small safe room and my gun jammed when BG crashed in on me.

But I see a lot of people advocating use of safe rooms. I'll have to have some construction work done to make mine safer.
One other consideration I haven't mentioned is my home alarm. I can hit the police panic button to immediately summon police (who will arrive sometime in the next half hour), but I think it sets off the siren also, which means I wouldn't be able to hear a darn thing. Hmm.
Very good point about there being additional BGs. You never know...