Hell if I had to, I would trust my fist to defend my life and will without hesitation I might add, however IMO, the .25ACP x 9 rounds is by no means something to sneeze at. The proper round choice "FMJ" is the key to defense with the minimal calibers. That, coupled with placement + quantity will / should provide the victim the time to evade the attack, if it doesn't put the punk down out right. Just my opinion YMMV.
Oh, and I carry the .25ACP 950 BS as a BUG to my primary and feel very well armed against the everyday thug. In fact I'd say; the poor loser that causes me to pull either to defend my life will be very sorry for what they started.