When I started reloading back in the early 80s I just went with whatever was in my Lee load chart that came with powder dippers and never varied, now my range loads are a little more creative and all about accuracy. Everything else is secondary. It seems that more often than not there are no data for the exact bullet I'm using. For a new bullet design (using autoloaders), I'll determine the OAL I need via the plunk test. Based on that and manual reviews, I usually start with a batch at a mid-range load. If that just doesn't look like the accuracy I want (I'm NOT a great shot, so I'm looking at keeping all the hits within 3-4 in. at 15-20 yds), I'll move up and down by .02 gr and see if there is an improvement. Of course, not looking at other variables make this sound pretty simple, but things like powder selection, bullet weight and type, and what your gun "prefers" certainly play a big role, too.
Like so much dealing with shooting and reloading, there are more ways than one to arrive at your destination. Experiment within the bounds of safety and see what works for you.