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An assailant can be said to be having a very bad day if he's fairly hit with any .45 Colt load.
I don't generally stoke up my only .45 Colt for defensive duties and would use handloaded 250 grain SWC's if I did but have tried both the Federal and Winchester loads mentioned above that feature a 225 grain hollow point bullet and they were acceptably accurate and easily controllable. They look like a good choice.
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