Oh no, not another caliber debate! :tongue:
I tend to put more stock in real-world results such as wound analysis, morgue reports, gunfight accounts, etc. than from gelatin and "calculator" stats, and from everything I've seen on the subject, both are excellent "manstoppers" if there is such a thing. But the .357 has an excellent track record that is matched by few if any rounds, and its combat performance seems to defy the conventional wisdom on ballistic data. Its velocity and bullet design tends to compensate well for its reduced bullet weight.
That said, .45 is certainly no slouch and ranks way up there too. I prefer .45 because I prefer autos, and I like heavier bullets out of a SD handgun.
Personally I would say this particular decision boils down to more a revolver vs. auto preference. Choosing one or the other will tend to make the caliber decision for you (although there are a few exceptions, for practical SD purposes each round is better suited to one gun type or the other).