I saw the thread "Is the Semi-Automatic Firearm the Do-All and End-All For You?" go by. I think that's trying to cover too much ground. I wanted to tighten down that discussion to only cover defensive handguns.
So for the purposes of this poll/discussion, please base your response to purposes of defense against human attackers. If you have a need for self defense against large animals (thinking bears, wolves or other large predators), that would not be included in this discussion, nor would explicitly hunting handguns. There is of an overlap in the defensive use against more urban / suburban four legged potential attackers (aggressive domestic dogs, coyotes). In this case the primary purpose would be defense against humans, but having the capability of taking one of these animal if necessary could be considered.
Do you see a reason to use any gun other than a semi-auto either as a carry gun or emplaced available defensive gun (think nightstand or other non-carried HD gun)? As a semi-auto would be considered can be anything from a Seecamp to a Desert Eagle, but it must be of a recoil/gas powered self loading design.
So all that said...