Competition in the gun and ammo markets is such that self defense ammo from any of the major ammo makers should work well for you. They all want your money and they all put out a good product. Is Buffalo Bore a major maker? I don't know what your definition of "major" is. I like Federal EFMJ in my .45 acp, and Speer Gold Dot in my revolvers, but that's just me. Your mileage may vary.
Many times when someone asks for advice on the "best" of anything, you will get a wide variety of replies. Most will tell you what they carry, but how many have used that particular load to defend themselves? You will get a lot of statistics on ballistics and theory, but that is only helpful if you are attacked by a blob of ballistic Jell-o.
Who uses pistols for self defense, and does actual research on proven field experience on stopping power? Many police departments rely on FBI testing and research on actual shootings. Some of the larger departments do their own testing and research.
It may be worth while to see what your local cops are carrying, and why.