I've had few problems with 22 autos providing that (a) I used plated shells ($9 a brick as opposed to $6-7) and (b) kept them clean.
The Rugers work well, but I've had nothing but personal bad luck with them. That and I ended up with a Standard (not even a Mk 1) without the trigger fix of the Mk 1, and quite frankly, it's fundamentally dangerous. Chambering a round can and will occasionally (1 in 500 or so) detonate on chambering because there is no intermediary between the physical trigger and its' sear. I can't and won't sell it and I can't and won't shoot it any more. I know the problem's fixed in newer models that aren't from 1954, but....
I've had better luck with modern designs. Despite the space-gun looks, the old lady's Beretta Neos that we've had since they came out has been flawless. I clean it for her about once a season, and her idea of shooting is loading all 4 mags and making cans jump as fast as she can pull the trigger and reload so I estimate 500 or more per range visit. It goes a few k between cleanings and I only touch it when it starts to become a problem or if I'm feeling bored and want to clean guns. It used to need it every thousand or so with lead bullets, but once I switched her to plated....
If I want stupid accurate and one that honestly doesn't care about ammo, there's my evil Commie copy of the Walther Olympia. It'll feed anything and not care and put them in one hole. I have it mostly for the 4H kids but partly for those pesky varmints that you have to discreetly dispatch and be sure where the shell is going is only into varmintland.
The Sig Mosquito more than anything (and I've had one probably as long as anyone in the US now) is a training tool. It's not as accurate as my Olympia clone, but few things are. It's a hair more ammo picky than the Neos, and I feed it CCI Mini-mags almost exclusively. They're 2x as expensive as the normal brick, but I have 1 failure in 1k on average FTF and none FTE or FTL since the gun got broken in, and it goes 1k rounds between cleanings as opposed to 400. They're accurate to a point where you can be a danger to any pop can, AOL cd, or other plinking target out to the 50m berm, and well, it's the only 22LR I actually enjoy to shoot. The ammo is part of the deal - it gives a little more zing and report than the cheap fodder it also consumes. For me, it's a range toy and training tool, but you can have range toys once you hit the 20 or 30 gun mark. Since I hit that years ago, well, I can have a bunch.
If I were to pick one as a general purpose last ditch defense gun/varmint/hunting piece, it'd probably be the Olympia. Trigger pull is sinful, clocking in at 2 or so pounds. I warn students and give it to them with a snap cap to illustrate what they're about to learn on. All 8 rounds leave almost instantly if you know where the trigger reset is by muscle memory, and make one very nasty 1" hole out to 15m. I don't want to be on the receiving end of that, and it's accurate enough to pop small critters in the head as long as you can clearly see it.
If I wanted something in the exclusively defensive range, I'd stick with the Sig. I have serious reservations about the caliber, but the double-strike capability of the SA/DA trigger, extremely high quality magazines, and Mini-mags means that I have reasonable faith it'll go off for all 11 rounds. It's accurate enough. It just won't bring home dinner as reliably.