For large game which of the listed rounds is the best? I look for distance, lethality, and accuracy. To me the .270 meets all of those.
I prefer the 300 WSM to the 300 Win. mag.Voted other. If I could only pick one, I'd pick 300 Win. Mag. With proper loads, it will handle anything in North America. My second choice would be 45/70. Again, with proper loads it will take any game I may come across. If limited to one, I picked the Mag. over the 45/70 for it's flatter trajectory.