Only .22 pistol I own is a Browning Buckmark. Very easy to shoot and very accurate.
As long as you stick with ammo your gun "likes." you're at an advantage. However, .22 ammo in general is dirty, so keep your chamber clean. Fouling in the bore is less of an impediment to accuracy than a crudded-up chamber is to reliability. Every couple of hundred rounds, give your chamber a good scrub with a brush and solvent, followed with clean patches.I've owned a Ruger SR22 for about 4 years now and have had no reliability issues except when it was extremely dirty, then I would have several FTF issues at the range. Kept clean it operated faultlessly. I am very pleased with the operation and accuracy. Very fun to shoot and it doesn't cost a fortune. I use 40 gr. CCI maxi-mags.
I have both those guns and they are indeed a lot of fun and not fussy about ammo. It would be real hard for me to pick one as my favorite over the other. When my son and I go to the range it's surprising how fast we run through a brick of ammo with those two.My 2 favorite semi-auto .22's are both S&W M&P's. M&P 22 Compact and M&P 15-22. Both are very reliable even with crappy cheap bulk ammo