I point shoot regularly with both pistols and rifles. I'll ignore the rifle for the purposes of this discussion.
Sight picture? Nope. I just point and pull.
Stance? Nope. Point and pull, and in practice, I make sure to do it from awkward and uncomfortable positions.
Two hand? Nope. Too much time, and I could be better spending it drawing the BUG.
What I recommend for home training in a secured environment is making sure the weapon is unloaded (check twice if you're paranoid), and practice drawing or pointing at an object in the room or across the hall or whatnot. You can check your sight picture after the point if you'd like.
Do that for a while and regularly, and you'll learn by feel what your carry or other gun points at and how to adjust for it.