I think I'd keep my SP-101. It's compact but powerful with excellent reliability and should last me forever. Your $1500 price tag seems a bit high for what most folks are going to depend upon most. I think very few will legitimately pick a $1500 1911 or something like that.
If I only had one handgun it would have to serve all functions well - concealed carry, home defense and range use. So it would have to be compact enough to conceal but sturdy enough to handle lots of shooting. It should also be reliable and trouble-free, and in a "medium" caliber with readily available ammunition.
I believe I would go with the Sig P229 in .40 caliber, which can be converted to 9mm with a barrel and magazine change. It is the best all-around gun I have.
I could never get rid of my children. Though they are all a bit different, I love them all. That said in the middle of the night if I had to reach for one, it would be Lucille, the S&W 686+ (3" barrel) if Harriet the S&W Model 29 didn't get in the way.
One gun for all conceivable uses, Range, Defense, Concealed Carry and Hunting would best be served, IMHO, by a 4" .357 Magnum.
It will not excell at any of those uses, but will get the job done. If hunting and having to possibly put food on the table was not an issue then I may consider a Hi Power in .40 S&W with a .357 Sig Barrel and a "drop down" 9mm conversion barrel. That way I could shoot three calibers out of one gun with minor modifications. If parts availability was an issue, I'd get a Glock 23 or 32.
For me CC is important and deep conceal is what counts therefore it needs to be small and go bang every time with enough stopping power to be very effect. As to house defense ranges are across the room and down the hall. The one gun that fits all these for me is the Kel Tec P3AT loaded with CD ammo and crimson trace. Enough money left over to buy stock of ammo.
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