Everyone has pretty well given most of the reasons for leading.
Too fast,too slow, too soft,too hard.
I shoot lots and lots of lead bullets. I have little problem with leading.
One thing that I have done that made a major difference is to fire lap my barrels.
If you have a rough barrel, it doesn't matter what you do because you will be shearing lead off as the bullet passes. Polishing a barrel that is rough will iron out the high spots, polish the smoothh spots and make everything more uniform.What ever burrs you have will be removed.
Its like running a your hand down a silk stocking. If you have a smoot hand it'll be nice and easy.
If you have a rough calloused hand, you'll snag and tear up the stocking.
Barrels are no different. My Colt Anaconda had a rough barrel. Although sometimes you cant see the imperfections without a bore scope, it is obvous when the barrel leads up after only a few dozen rounds. I read an article about Fire Lapping in the Guns and Ammo magazine and I figured I had little to lose. I did just what it said to do and it made a big difference. Asa result of that, I can fire lots more with less effort to clean.
Another thing that helps are bullets that are consistent. I cast my own and I size and hot lube them. I have used commercially cast bullets that varied as much as .010 in diameter that caused much leading.
Since I haven't actually bought any lead bullets in years, I haven't had any problems.
Just something to think about.