Unless you are psychic and somehow know ahead of time in which order you will need a particular type of ammo, I wouldn't recommend it. Most major ammo makers have one or more kinds of ammo especially made for self defense and should perform well. Look for the brands that perform well (expand & penetrate) through common barriers, glass, dry wall, leather, denim, etc.anyone on here mix different types of hollow points in a single magazie? what's your reason? pros and cons? advantages/dis-advantages?
Like he said it's really not mixing up a mag, but the only thing I do close to it is I put a slug in my shotgun, followed by all buckshot and I only do this when I'm on duty, because the only thing I'd use a slug for is blowing a lock on a house or stopping a car.Also I guess you can mix in a slug as needed into a shotgun, but that isn't really mixing it up in the mag.